Article No
182-HM1115F-100UG
Specifications
| Application | FC, IA, WB |
| Article No | 182-HM1115F-100UG |
| Country Availability | SE, FI, DK, NO, EE, LV, LT |
| Clone | 3D5 |
| Clone Type | monoclonal |
| Conjugation | FITC |
| Description | CD55 |
| Supplier | Hycult biotechnology |
| Format | 1 ml (100 μg/ml) 0.2 μm protein G purified FITC conjugated antibody solution in PBS, containing 1% bovine serum albumin and 0.02% sodium azide. |
| Immunogen | NRK cells expressing transmembrane-anchored mouse DAF |
| Isotype | IgG2a |
| Notes | The monoclonal antibody 3D5 recognizes complement decay accelerating factor (DAF), also designated as CD55. Cells express on their surface several proteins which protect against complement attack, namely C receptor I (CR1), decay accelerating factor, membrane cofactor protein (MCP) and CD59. CR1, CD55 and MCP regulate the activation pathways of complement by either accelerating decay of the C3 and C5 convertase (CR1, CD55), or acting as cofactors for the serine protease factor I, which cleaves and irreversibly inactivates C3b (CR1, MCP). Mouse CD55 is a 60 kDa transmembrane protein that binds C3b and C4b to inhibit formation and half-life of the C3 convertases. CD55 is broadly distributed among cells in contact with serum, including both haematopoietic and nonhaematopoietic cells. Although CD55 does not have an essential role in controlling hemolysis of erythrocytes, it has an important role in regulation of the deposition of C3 on nucleated cells. Together with other complement regulators CD55 protects self-cells from autologous complement-mediated injury. CD55 cooperates with CD46 in circumventing autologous C3 deposition, while CD59 inhibits the pathway at the critical end-point. |
| Alias Names | Complement decay-accelerating factor, GPI-anchored, DAF-GPI Gene name: Cd55, Cd55a, Daf, Daf1 |
| Previous Article No | 182-HM1115F, 182-HM1115F-100UG, HM1115F-100UG |
| Product Type | Antibodies Primary |
| Research area | Immunology |
| Shipping Information | Room Temperature |
| Size | 100µg |
| Source / Host | rat |
| Species Reactivity | mouse |
| Storage | Product should be stored at 4°C. Under recommended storage conditions, product is stable for one year. |
| Substrate / Buffer | 0.2 ml (100 μg/ml) 0.2 μm protein G purified FITC conjugated antibody solution in PBS, containing 1% bovine serum albumin and 0.02% sodium azide. |
| Product Page Updated | 2023-12-29T14:10:53.573Z |
