Article No
182-HM1063-100UG
Collagen II, Mouse, mAb M2139 – 100 µg
Collagen II, Mouse, mAb M2139 – 100 µg
Antibodies Primary
Specifications
| Application | FS, IA |
| Article No | 182-HM1063-100UG |
| Country Availability | SE, FI, DK, NO, EE, LV, LT |
| Clone | M2139 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Collagen II, Mouse, mAb M2139 – 100 µg |
| Supplier | Hycult biotechnology |
| Format | 1 ml (100 μg/ml) 0.2 μm filtered protein G purified antibody solution in PBS, containing 0.1% bovine serum albumin. |
| Isotype | IgG2b |
| Notes | The monoclonal antibody M2139 reacts with the J1 epitope (triple helical position 551-564) of collagen type II. Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA). The monocolonal antibody M2139 has been shown to induce CAIA in naïve mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody CIIC1, binding to the C1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity. |
| Previous Article No | 182-HM1063, 182-HM1063-100UG, HM1063-100UG |
| Product Type | Antibodies Primary |
| Research area | Immunology, Metabolism |
| Shipping Information | Room Temperature |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | mouse |
| Storage | Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year. |
| Substrate / Buffer | Quantities >500 µg will be send without preservative and carrier free. Quantities |
| Product Page Updated | 2024-04-05T09:42:44.568Z |