Article No
182-HC2120-50UG
Calprotectin, Human, Recombinant
Calprotectin, Human, Recombinant
Proteins & Peptides
Specifications
| Application | FS |
| Article No | 182-HC2120-50UG |
| Country Availability | SE, FI, DK, NO, EE, LV, LT |
| Description | Calprotectin, Human, Recombinant |
| Supplier | Hycult biotechnology |
| Format | Lyophilized product in 74mM Tris-HCl and 104mM NaCl, pH7.4 containing 50 µg human Calprotectin. Reconstitute the vial by pipetting 0.5 ml distilled or de-ionised water (Caution: vial is under vacuum). |
| Notes | Calprotectin, also known as MRP-8/MRP-14 or S100A8/A9 heterocomplex, is formed out of the calcium-binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9). The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is calcium-dependent. Calprotectin comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, neutrophils only intracellularly. Calprotectin has antibacterial, antifungal, immunomodulating and antiproliferative effects. Furthermore, it is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity. During intestinal wall inflammation, granulocytes transmigrate through the intestinal wall. Therefore calprotectin is also detectable in faeces. Several investigations report that faecal calprotectin is significantly increased in intestinal diseases such as inflammatory bowel disease (IBD), Crohn's disease, ulcerative colitis and colon cancer. Normal human plasma contains a calprotectin concentration ranging from 500 to 3000 ng/ml. |
| Previous Article No | 182-HC2120, 182-HC2120-50UG, HC2120-50UG |
| Product Type | Proteins & Peptides |
| Research area | Cell Death, Immunology |
| Shipping Information | Room Temperature |
| Size | 50 µg |
| Source / Host | human |
| Species Reactivity | human |
| Storage | Product should be stored at -70 °C. Repeated freeze and thaw cycles will cause loss of activity. The exact expiry date is indicated on the label. Use recombinant Calprotectin protein within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year. |
| Substrate / Buffer | Lyophilized product in 74mM Tris-HCl and 104mM NaCl, pH7.4 containing 50 µg human Calprotectin. Reconstitute the vial by pipetting 0.5 ml distilled or de-ionised water (Caution: vial is under vacuum). |
| Product Page Updated | 2024-04-05T09:42:44.568Z |