Article No
155-99-607
Specifications
| NCBI Number | 3920 |
| Accession Number | P13473 |
| Application | ELISA, FC, IHC |
| Article No | 155-99-607 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | H4B4 |
| Clone Type | monoclonal |
| Concentration | Lot specific |
| Conjugation | PE/Cy5 |
| Description | CD107b Antibody [H4B4] (PE-Cy5) |
| Supplier | ProSci |
| Entrez Gene ID | 3920 |
| Format | Liquid |
| Gene Symbol | LAMP2 |
| Immunogen | Human adherent peripheral blood cells |
| Isotype | IgG1 |
| Notes | CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains and is a ligand for E-selectin-mediated cell adhesion. CD107b is expressed in lysosomal/endosomal membranes and on the surface of activated platelets and some tumor cell lines including U937 and KG1a. LAMP-2 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium. |
| Alias Names | LAMP-2, lysosome-associated membrane protein 2 |
| Previous Article No | 155-99-607-100 |
| Product Type | Antibodies Primary |
| Protocol | CD107b Antibody [H4B4] for use in flow cytometry assays. |
| Research area | Immunology, Metabolism |
| Shipping Information | BLUE ICE |
| Size | 100 tests |
| Source / Host | mouse |
| Species Reactivity | human, monkey |
| Storage | 4°C |
| Substrate / Buffer | Supplied in PBS/NaN3 and a stabilizing agent |
| Technical Specifications | CD107b Antibody [H4B4] for use in flow cytometry assays. |
| UniProt Number | P13473 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
