Article No
155-99-408
Specifications
| NCBI Number | 7412 |
| Accession Number | P19320 |
| Application | Cell Separation, Depletion, FC, ICC, IHC, IP |
| Article No | 155-99-408 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 1.G11B1 |
| Clone Type | monoclonal |
| Concentration | 0.1 mg/ml |
| Conjugation | Unconjugated |
| Description | CD106 Antibody [1.G11B1] |
| Supplier | ProSci |
| Entrez Gene ID | 7412 |
| Format | Liquid |
| Gene Symbol | VCAM1 |
| Isotype | IgG1 |
| Notes | CD106, also known as INCAM-110, is a 110 kDa vascular adhesion cell adhesion molecule-1 (VCAM-1) that is member of the immunoglobulin superfamily. CD106 is expressed predominantly on cytokine-activated vascular endothelium but has also been identified on interfollicular dendritic cells, some macrophages, and bone marrow stromal cells. Endothelial CD106 binds the integrins alpha4beta1 (CD49d/CD29, VLA-4) and alpha4beta7 and contributes to extravasation of lymphocytes, monocytes, basophils, and eosinophils (but not neutrophils) from blood vessels, particularly at sites of inflammation. Unlike the beta2 integrins, the CD106-VLA-4 interaction can mediate both the initial tethering and rolling of lymphocytes on endothelium as well as their subsequent arrest and firm adhesion. CD106 expressed on non-vascular tissues has been implicated in the interaction of hematopoietic progenitors with bone marrow stromal cells, B cell binding to follicular dendritic cells, costimulation of T cells, and embryonic development. The monoclonal antibody 1.G11B1 inhibits in vitro binding of lymphocytes and monocytes to VCAM-1 on stimulated endothelium. |
| Alias Names | VCAM-1, INCAM-110, vascular cell adhesion molecule-1 |
| Previous Article No | 155-99-408-0.1 |
| Product Type | Antibodies Primary |
| Protocol | CD106 Antibody [1.G11B1] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, ELISA, adhesion, and blocking assays. |
| Research area | Neuroscience |
| Shipping Information | BLUE ICE |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human, pig/porcine |
| Storage | 4°C |
| Substrate / Buffer | Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added |
| Technical Specifications | CD106 Antibody [1.G11B1] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, ELISA, adhesion, and blocking assays. |
| UniProt Number | P19320 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
