Article No
155-98-767
NCBI Number | 21939 |
Accession Number | P27512 |
Application | FC, IHC, IP, WB |
Article No | 155-98-767 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | 1C10 |
Clone Type | monoclonal |
Concentration | 0.1 mg/ml |
Conjugation | PE/Cy5 |
Description | CD40 Antibody [1C10] (PE-Cy5) |
Supplier | ProSci |
Entrez Gene ID | 21939 |
Format | Liquid |
Gene Symbol | Cd40 |
Immunogen | sCD40 |
Isotype | IgG2a |
Notes | CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow with the levels of CD40 expression increasing thereafter during B cell maturation. Immature B cells (IgM+IgDloB220lo) express intermediate levels of CD40, whereas mature B cells (IgM+IgDhiB220hi) express high levels. CD40 has a central role in B cell growth and differentiation, and signaling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE. The agonistic 1C10 antibody closely resembles gp39/CD40 ligand in its ability to stimulate proliferation of small, resting B lymphocytes in the absence of other cofactors. |
Alias Names | TNFRSF5, Bp50 |
Previous Article No | 155-98-767-0.1 |
Product Type | Antibodies Primary |
Protocol | CD40 Antibody [1C10] for use in flow cytometry assays. |
Research Area | Immunology |
Shipping Information | BLUE ICE |
Size | 0.1 mg |
Source / Host | rat |
Species Reactivity | mouse |
Storage | 4°C |
Substrate / Buffer | Supplied in PBS/NaN3 and a stabilizing agent |
Technical Specifications | CD40 Antibody [1C10] for use in flow cytometry assays. |
UniProt Number | P27512 |
Product Page Updated | 2024-01-03T13:34:25.701Z |