Article No
155-97-033
CTLA-4 Recombinant Protein
CTLA-4 Recombinant Protein
Proteins & Peptides
Specifications
| MW | 40.3 kDa |
| NCBI Number | 100009412 |
| Accession Number | P42072 |
| Application | WB |
| Article No | 155-97-033 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Description | CTLA-4 Recombinant Protein |
| Supplier | ProSci |
| Entrez Gene ID | 100009412 |
| Format | Lyophilized |
| Gene Symbol | CTLA4 |
| Notes | CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis. |
| Alias Names | CTLA4,CD152,CELIAC3,GRD4,GSE,ICOS,IDDM12 |
| Previous Article No | 155-97-033-$100, 155-97-033-100 |
| Product Type | Proteins & Peptides |
| Protocol | This recombinant protein can be used for WB. For research use only. |
| Purity | >95% |
| Research area | Immunology |
| Sequence | Lys 36 - Asp 161 |
| Shipping Information | RT |
| Size | 0.1 mg |
| Storage | -20°C, -80°C |
| Substrate / Buffer | Tris with Glycine, Arginine and NaCl, pH7.5 |
| UniProt Number | P42072 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
