14-3-3 Beta

Article No 155-96-781-0.1
Product Type Proteins & Peptides
Research Area Cell Proliferation
Application WB
Format Lyophilized
Size 0.1 mg

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MW 55 kDa
Country Availability DK, EE, FI, FO, GL, IS, LT, LV, NO, SE
Data Sheet Link http://www.prosci-inc.com/pdf.php?sku=96-781
Description 14-3-3 Beta Recombinant Protein
Supplier ProSci incorporated
Notes Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (YWHAB) is also known as 14-3-3 protein beta, GW128, HS1. YWHAB belongs to the 14-3-3 family. YWHAB binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. YWHAB is negative regulator of osteogenesis. YWHAB blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.
Alias Names YWHAB, KCIP-1, 14-3-3 beta, GW128, HS1
Purity >95% as determined by SDS-PAGE.
References Liu Y., et al., 2007, Mol. Endocrinol. 21:3050-3061.
Size 0.1
Source / Host bacteria
Species Reactivity human
Storage Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Substrate / Buffer 50 mM Tris, 150 mM NaCl, pH 7.4
Product Page Updated 2019-01-08T16:04:55.621Z

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Species reactivity:

human human

Product insert:

Product data sheet


Suggested protocols:

Western Blot

Western Blot