Article No
155-96-723
MW | 20.7 kDa |
NCBI Number | 84868 |
Accession Number | Q8TDQ0 |
Application | WB |
Article No | 155-96-723 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Description | TIM3 Recombinant Protein |
Supplier | ProSci |
Entrez Gene ID | 84868 |
Format | Lyophilized |
Gene Symbol | HAVCR2 |
Notes | Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis. |
Alias Names | HAVCR2, TIM3, TIMD3, FLJ14428, KIM3 |
Previous Article No | 155-96-723-0.1 |
Product Type | Proteins & Peptides |
Protocol | This recombinant protein can be used for WB. For research use only. |
Purity | >95% |
Sequence | Ser 22 - Arg 200 |
Shipping Information | RT |
Size | 0.1 mg |
Storage | -20°C, -80°C |
Substrate / Buffer | PBS, pH7.4 |
Technical Specifications | Immobilized Human TIM-3, His Tag at 0.2ug/mL (100uL/well) can bind Anti-TIM3 MAb, Human IgG4 with a linear range of 0.2-6 ng/mL. |
UniProt Number | Q8TDQ0 |
Product Page Updated | 2024-01-03T13:34:25.701Z |