Article No
155-90-426
CD273 [PD-L2] non-lytic Recombinant Protein
CD273 [PD-L2] non-lytic Recombinant Protein
Proteins & Peptides
Specifications
| NCBI Number | 80380 |
| Accession Number | NP_079515 |
| Article No | 155-90-426 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Description | CD273 [PD-L2] non-lytic Recombinant Protein |
| Supplier | ProSci |
| Entrez Gene ID | 3565,80380 |
| Format | Lyophilized |
| Gene Symbol | IL4, PDCD1LG2 |
| Notes | T cells require a signal induced by the engagement of the T cell receptor and a €œcostimulatory€ signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals. |
| Alias Names | PD-L2, Programmed Cell Death 1 Ligand 2, PDCD1 Ligand 2, B7-DC, PDL2 |
| Previous Article No | 155-90-426-100 |
| Product Type | Proteins & Peptides |
| Protocol | This recombinant proteins is for research use only. |
| Purity | >98% |
| Research area | Cell Death |
| Sequence | The extracellular domain of human CD273 [PD-L2] (aa 20-219) is fused to the N-terminus of the Fc region of a mutant human IgG1. |
| Shipping Information | RT |
| Size | 100 ug |
| Storage | -20°C |
| Substrate / Buffer | Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μg/ml in sterile PBS. |
| Technical Specifications | Shows the biological function of the CD273 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. |
| UniProt Number | P05112 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
