Article No
155-90-225
CD40L multimeric Recombinant Protein
CD40L multimeric Recombinant Protein
Proteins & Peptides
Specifications
| NCBI Number | 959 |
| Accession Number | P29965 |
| Article No | 155-90-225 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Concentration | 0.1 mg/ml |
| Description | CD40L multimeric Recombinant Protein |
| Supplier | ProSci |
| Entrez Gene ID | 27242,959 |
| Format | Lyophilized |
| Gene Symbol | CD40LG, TNFRSF21 |
| Notes | MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to [CD40L+enhancer] combinations. MultimericCD40L™ has shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced. |
| Alias Names | ACRP30headless:CD40L, ACRP30headless:CD154, ACRP30headless:TNFSF5, ADIPOQ-CD40L |
| Previous Article No | 155-90-225-10 |
| Product Type | Proteins & Peptides |
| Protocol | This recombinant proteins is for research use only. |
| Purity | >95% |
| Research area | Cell Death |
| Sequence | Human CD40L (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a DDDDK-tag. |
| Shipping Information | RT |
| Size | 10 ug |
| Storage | -20°C |
| Substrate / Buffer | Contains PBS Reconstitute with 100 μl sterile water. |
| Technical Specifications | Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86) (ED50: <1ng/ml). |
| UniProt Number | O75509, P29965 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
