Article No
155-76-849
Specifications
| NCBI Number | 12477 |
| Application | FC |
| Article No | 155-76-849 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | UC10-4F10-11 |
| Clone Type | monoclonal |
| Concentration | batch dependent |
| Conjugation | Unconjugated |
| Description | CD152 Antibody [UC10-4F10-11] |
| Supplier | ProSci |
| Entrez Gene ID | 12477 |
| Format | Liquid |
| Gene Symbol | Ctla4 |
| Isotype | IgG |
| Notes | The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes. |
| Alias Names | Cd152, Ly-56, Ctla-4, Ctla4 |
| Previous Article No | 155-76-849-0.1 |
| Product Type | Antibodies Primary |
| Purification | Affinity Purified |
| Research area | Immunology |
| Shipping Information | BLUE ICE |
| Size | 0.1 mg |
| Source / Host | hamster |
| Species Reactivity | mouse |
| Storage | 4°C |
| Substrate / Buffer | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
| UniProt Number | P09793 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
