Antibodies Primary

CD152

NEW
CD152 Antibody [BNI3] (APC)

Article No

155-76-847-100

Application

FC

Species Reactivity

human

Size

100 tests

Clone

BNI3

Source / Host

mouse

Product insert

Specifications

Application FC
Article No 155-76-847-100
Country Availability DK, EE, FI, FO, GL, IS, LT, LV, NO, SE
Clone BNI3
Clone Type monoclonal
Concentration 5 uL (0.125 ug) / test
Conjugation APC
Description CD152 Antibody [BNI3] (APC)
Supplier ProSci incorporated
Format Liquid
Isotype IgG2a k
Notes The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4). CTLA-4 is expressed on activated CD28+ T cells, and binds the B7 family members B7-1 (CD80) and B7-2 (CD86). The structure of CTLA-4 is similar to the structure of CD28, but the two molecules seem to have opposite roles on the T lymphocytes. CTLA-4 inhibits the progression of T cell activation, while CD28 stimulates it. This result explains the stimulating role that the immobilization of BNI3 plays on the T lymphocytes proliferation induced by CD28.
Alias Names CD, GSE, GRD4, ALPS5, CD152, CTLA-4, IDDM12, CELIAC3, CTLA4
Product Type Antibodies Primary
Purification The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
References Alegre, M. L., Noel, P. J., Eisfelder, B. J., Chuang, E., Clark, M. R., Reiner, S. L., Thompson, C. B. (1996). Regulation of surface and intracellular expression of CTLA4 on mouse T cells.The Journal of Immunology,157(11), 4762-4770.
Research Area Immunology
Size 100 tests
Source / Host mouse
Species Reactivity human
Storage The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze.
Substrate / Buffer Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Product Page Updated 2019-01-08T13:53:07.487Z

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