Article No
155-76-842
NCBI Number | 1493 |
Application | FA, FC, IHC, IP |
Article No | 155-76-842 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | BNI3 |
Clone Type | monoclonal |
Concentration | batch dependent |
Conjugation | Unconjugated |
Description | CD152 Antibody [BNI3] |
Supplier | ProSci |
Entrez Gene ID | 1493 |
Format | Liquid |
Gene Symbol | CTLA4 |
Isotype | IgG2a k |
Notes | The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4). CTLA-4 is expressed on activated CD28+ T cells, and binds the B7 family members B7-1 (CD80) and B7-2 (CD86). The structure of CTLA-4 is similar to the structure of CD28, but the two molecules seem to have opposite roles on the T lymphocytes. CTLA-4 inhibits the progression of T cell activation, while CD28 stimulates it. This result explains the stimulating role that the immobilization of BNI3 plays on the T lymphocytes proliferation induced by CD28. |
Alias Names | CD, GSE, GRD4, ALPS5, CD152, CTLA-4, IDDM12, CELIAC3, CTLA4 |
Previous Article No | 155-76-842-0.1 |
Product Type | Antibodies Primary |
Purification | Affinity Purified |
Research area | Immunology |
Shipping Information | BLUE ICE |
Size | 0.1 mg |
Source / Host | mouse |
Species Reactivity | human |
Storage | 4°C |
Substrate / Buffer | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
UniProt Number | P16410 |
Product Page Updated | 2024-01-03T13:34:25.701Z |