Article No
155-76-040
Specifications
| NCBI Number | 12519 |
| Application | FA, FC, IF, IHC, IP |
| Article No | 155-76-040 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 16-10A1 |
| Clone Type | monoclonal |
| Concentration | batch dependent |
| Conjugation | Unconjugated |
| Description | CD80 Antibody [16-10A1] |
| Supplier | ProSci |
| Entrez Gene ID | 12519 |
| Format | Liquid |
| Gene Symbol | Cd80 |
| Isotype | IgG |
| Notes | The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. |
| Alias Names | B71, Ly53, TSA1, Cd28l, Ly-53, MIC17, Cd80 |
| Previous Article No | 155-76-040-0.1 |
| Product Type | Antibodies Primary |
| Purification | Affinity Purified |
| Shipping Information | BLUE ICE |
| Size | 0.1 mg |
| Source / Host | hamster |
| Species Reactivity | mouse |
| Storage | 4°C |
| Substrate / Buffer | Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
| UniProt Number | Q00609 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
