Article No
155-76-035
Specifications
| NCBI Number | 941 |
| Application | FA, FC |
| Article No | 155-76-035 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 2D10.4 |
| Clone Type | monoclonal |
| Concentration | batch dependent |
| Conjugation | Unconjugated |
| Description | CD80 Antibody [2D10.4] |
| Supplier | ProSci |
| Entrez Gene ID | 941 |
| Format | Liquid |
| Gene Symbol | CD80 |
| Isotype | IgG1 k |
| Notes | The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. |
| Alias Names | B7, BB1, B7-1, B7.1, LAB7, CD28LG, CD28LG1, CD80 |
| Previous Article No | 155-76-035-0.5 |
| Product Type | Antibodies Primary |
| Purification | Affinity Purified |
| Research area | Immunology |
| Shipping Information | BLUE ICE |
| Size | 0.5 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C |
| Substrate / Buffer | Phosphate-buffered aqueous solution, ph7.2. |
| UniProt Number | P33681 |
| Product Page Updated | 2024-01-03T13:34:25.701Z |
