Antibodies Primary

Choline Acetyltransferase

NEW
Choline Acetyltransferase Antibody

Article No

155-50-265-0.1

Application

WB, IHC

Species Reactivity

human
mouse
rat
goat
chicken

Size

0.1 mL

Source / Host

goat

Product insert

Suggested protocols

Specifications

MW 70
Application WB, IHC
Article No 155-50-265-0.1
Country Availability DK, EE, FI, FO, GL, IS, LT, LV, NO, SE
Clone Type polyclonal
Conjugation Unconjugated
Description Choline Acetyltransferase Antibody
Supplier ProSci incorporated
Format Liquid
Immunogen Native choline acetyltransferase purified from human placenta.
Notes Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).
Alias Names CMS1A, CMS1A2, CHOACTASE, CHOACTase
Product Type Antibodies Primary
Purification Affinity Purified
References Karson CN, Casanova MF, Kleinman JE, Griffin WS (1993) Choline acetyltransferase in schizophrenia. Am. J.Psychiatry 150:454-459.
Research Area Neuroscience
Size 0.1 mL
Source / Host goat
Species Reactivity human, mouse, rat, goat, chicken
Storage Choline Acetyltransferase antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Substrate / Buffer 100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
Product Page Updated 2019-01-08T13:53:07.487Z

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