Antibodies Primary

GABAA Receptor

NEW
GABAA Receptor Antibody

Article No

155-50-212-0.1

Application

WB

Species Reactivity

human
mouse
rat
dog/canine
zebrafish
cow/bovine
chicken
frog

Size

0.1 mL

Source / Host

rabbit

Product insert

Suggested protocols

Specifications

MW 55
Application WB
Article No 155-50-212-0.1
Country Availability DK, EE, FI, FO, GL, IS, LT, LV, NO, SE
Clone Type polyclonal
Conjugation Unconjugated
Description GABAA Receptor Antibody
Supplier ProSci incorporated
Format Liquid
Immunogen Fusion protein from the cytoplasmic loop of the b1-subunit of rat GABAA receptor.
Notes Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).
Alias Names GARB1, Gabrb-1,
Product Type Antibodies Primary
Protocol The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, chicken, human, mouse, non-human primate, Xenopus, and zebra fish based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Purification Affinity Purified
References Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ (2003) A kinase anchoring protein 79/150 facilitates the phosphorylation of GABAA receptors by cAMP-dependent protein kinase via selective interaction with receptor β-subunits. Mol Cell Neurosci 22:87-97.
Research Area Neuroscience
Size 0.1 mL
Source / Host rabbit
Species Reactivity human, mouse, rat, dog/canine, zebrafish, cow/bovine, chicken, frog
Storage GABAA Receptor antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Substrate / Buffer 100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
Product Page Updated 2019-01-08T13:53:07.487Z

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