Article No
155-40-308-0.02
TACI Recombinant Protein
TACI Recombinant Protein
Proteins & Peptides
Specifications
| NCBI Number | 23495 |
| Accession Number | NP_036584.1 |
| Article No | 155-40-308-0.02 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Description | TACI Recombinant Protein |
| Supplier | ProSci |
| Entrez Gene ID | 23495 |
| Format | Lyophilized |
| Gene Symbol | TNFRSF13B |
| Notes | TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription factors; NF-kappaB, AP-1, and mediates calcineurin dependent activation of NF-AT (nuclear-factor of activated T cells). TACI also plays a key role in the stimulation of B and T cell function. Soluble TACI inhibits APRIL-stimulated proliferation of primary B-cells by blocking the binding of APRIL to the membrane anchored TACI receptor. Recombinant human TACI is a soluble 160 amino acid polypeptide (17.8 kDa) comprising the TNFR homologous cysteine rich extracellular domain of the TACI protein. |
| Alias Names | CVID, RYZN, TACI, CD267, CVID2, TNFRSF14B, Tumor necrosis factor receptor superfamily member 13B, Transmembrane activator and CAML interactor |
| Product Type | Proteins & Peptides |
| Purity | >98% |
| Research area | Cell Death |
| Sequence | MSGLGRSRRG GRSRVDQEER FPQGLWTGVA MRSCPEEQYW DPLLGTCMSC KTICNHQSQR TCAAFCRSLS CRKEQGKFYD HLLRDCISCA SICGQHPKQC AYFCENKLRS PVNLPPELRR QRSGEVENNS DNSGRYQGLE HRGSEASPAL PGLKLSADQV |
| Shipping Information | RT |
| Size | 0.02mg |
| Storage | The lyophilized TACI recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TACI is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing TACI recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. |
| Technical Specifications | Biological activity was determined by its ability to block human BAFF induced T2B cell survival using a concentration range of 1.0 - 3.0 μg/mL. |
| UniProt Number | O14836 |
| Product Page Updated | 2024-01-03T13:15:21.507Z |
