Article No
155-40-286-0.002
Flt3 Ligand Recombinant Protein
Flt3 Ligand Recombinant Protein
Proteins & Peptides
Specifications
| NCBI Number | 2323 |
| Accession Number | NP_001191431.1 |
| Article No | 155-40-286-0.002 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Description | Flt3 Ligand Recombinant Protein |
| Supplier | ProSci |
| Entrez Gene ID | 2323 |
| Format | Lyophilized |
| Gene Symbol | FLT3LG |
| Notes | Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand exerts no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant human Flt3-Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues. |
| Alias Names | FL, FLT3L, Fms-related tyrosine kinase 3 ligand, SL cytokine, Flt3 ligand |
| Product Type | Proteins & Peptides |
| Purity | >98% |
| Sequence | TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA |
| Shipping Information | RT |
| Size | 0.002mg |
| Storage | The lyophilized Flt3 Ligand recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Flt3 Ligand is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing Flt3 Ligand recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature. |
| Technical Specifications | The ED50 was determined by the dose - dependent stimulation of the proliferation of human AML5 cells is ≤ 1.0 ng/mL, corresponding to a specific activity of ≥ 1 x 10<sup>6</sup> units/mg. |
| UniProt Number | P49771 |
| Product Page Updated | 2024-01-03T13:15:21.507Z |
