Article No
155-32-218
NCBI Number | 6653 |
Accession Number | Q92673 |
Application | ELISA, WB |
Article No | 155-32-218 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | 7D7B11 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | SORL1 Antibody [7D7B11] |
Supplier | ProSci |
Entrez Gene ID | 6653 |
Gene Symbol | SORL1 |
Immunogen | Purified truncated recombinant SORL1 (aa2159-2214)-MBP fusion protein is expressed in E. Coli strain BL21 (DE3). |
Isotype | IgG1 |
Notes | SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas._x000D_ |
Alias Names | C11orf32, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, LDLR relative with 11 ligand-binding repeats, LR11, LRP9, SORLA, gp250, SorLA-1, C11orf32 |
Previous Article No | 155-32-218-0.1 |
Product Type | Antibodies Primary |
Protocol | Western Blot:1:500 - 1:2,000 ELISA:Propose dilution 1:10,000. Determining optimal working dilutions by titration test. |
Research Area | Neuroscience |
Shipping Information | BLUE ICE |
Size | 0.1 mL |
Source / Host | mouse |
Species Reactivity | human |
Storage | SORL1 monoclonal antibody can be stored at -20°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Substrate / Buffer | Ascitic fluid containing 0.03% sodium azide. |
UniProt Number | Q92673 |
Product Page Updated | 2024-01-03T13:34:25.701Z |