Article No
154-21498
Chemicals & Biochemicals
(+)-Aeroplysinin-1
(+)-Aeroplysinin-1
Specifications
| CAS No | 28656-91-9 |
| Additional Information | A sea sponge metabolite with diverse biological activities; induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner from 0.25-0.5 μM; blocks EGF-induced endocytosis of EGFR and EGF-dependent cell proliferation in MCF-7 cells; inhibits BAE cell proliferation and cord formation in a Matrigel™ assay; inhibits angiogenesis in a CAM assay from 1.5-3 nmol per egg; has antibacterial activity against Gram-positive bacteria; inhibits HIV-1 replication (IC50 = 14.6 μM) |
| Article No | 154-21498 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, RU |
| Description | (+)-Aeroplysinin-1 |
| Supplier | Cayman Chemical |
| Format | A solid |
| Keywords | Small Molecule Inhibitors |
| Notes | (+)-Aeroplysinin-1 is a metabolite originally isolated from the marine sponge V. aerophoba with diverse biological activities.{42142} (+)-Aeroplysinin-1 (0.25-0.5 μM) induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner but has no effect on normal human fibroblasts at concentrations up to 5 μM.{42143} It also blocks EGF-induced endocytosis of the EGF receptor (EGFR) and EGF-dependent cell proliferation in MCF-7 cells. (+)-Aeroplysinin-1 inhibits bovine aortic endothelial (BAE) cell proliferation and cord formation in a Matrigel™ assay.{42144} It inhibits angiogenesis in a dose-dependent manner in a chick chorioallantoic membrane (CAM) assay when administered from 1.5 to 3 nmol per egg. (+)-Aeroplysinin-1 also has antibacterial activity against Gram-positive bacteria, including S. aureus, S. albus, and B. subtilis, but not Gram-negative bacteria and inhibits HIV-1 replication (IC50 = 14.6 μM) via inhibition of HIV-1 reverse transcriptase.{42145} |
| Alias Names | NSC 170364 |
| Product Type | Chemicals & Biochemicals |
| Purity | ≥95% |
| Shipping Information | -20 |
| Size | 100 µg |
| Storage | -20 |
| Substrate / Buffer | A solid |
| Product Page Updated | 2022-01-10T14:57:25.520Z |
Shipping info
The delivery time for this item is approximately 8-10 business days.
If other deviations occur, this will be noted on the order confirmation or communicated via email.
Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.