Article No
154-21498
CAS No | 28656-91-9 |
Additional Information | A sea sponge metabolite with diverse biological activities; induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner from 0.25-0.5 μM; blocks EGF-induced endocytosis of EGFR and EGF-dependent cell proliferation in MCF-7 cells; inhibits BAE cell proliferation and cord formation in a Matrigel™ assay; inhibits angiogenesis in a CAM assay from 1.5-3 nmol per egg; has antibacterial activity against Gram-positive bacteria; inhibits HIV-1 replication (IC50 = 14.6 μM) |
Article No | 154-21498 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, RU |
Description | (+)-Aeroplysinin-1 |
Supplier | Cayman Chemical |
Format | A solid |
Keywords | Small Molecule Inhibitors |
Notes | (+)-Aeroplysinin-1 is a metabolite originally isolated from the marine sponge V. aerophoba with diverse biological activities.{42142} (+)-Aeroplysinin-1 (0.25-0.5 μM) induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner but has no effect on normal human fibroblasts at concentrations up to 5 μM.{42143} It also blocks EGF-induced endocytosis of the EGF receptor (EGFR) and EGF-dependent cell proliferation in MCF-7 cells. (+)-Aeroplysinin-1 inhibits bovine aortic endothelial (BAE) cell proliferation and cord formation in a Matrigel™ assay.{42144} It inhibits angiogenesis in a dose-dependent manner in a chick chorioallantoic membrane (CAM) assay when administered from 1.5 to 3 nmol per egg. (+)-Aeroplysinin-1 also has antibacterial activity against Gram-positive bacteria, including S. aureus, S. albus, and B. subtilis, but not Gram-negative bacteria and inhibits HIV-1 replication (IC50 = 14.6 μM) via inhibition of HIV-1 reverse transcriptase.{42145} |
Alias Names | NSC 170364 |
Product Type | Chemicals & Biochemicals |
Purity | ≥95% |
Shipping Information | -20 |
Size | 100 µg |
Storage | -20 |
Substrate / Buffer | A solid |
Product Page Updated | 2022-01-10T14:57:25.520Z |