Antibiotics & Culture Media



Article No



1 g

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CAS No 2022-85-7
Additional Information An antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil, a cytotoxic drug that inhibits viral infections and has cytotoxic effects on cancer cells
Article No 154-11635-1
Country Availability SE, FI, DK, NO, IS, EE, LV, LT, FO, RU
Description 5-Fluorocytosine
Supplier Cayman Chemical
Format A crystalline solid
Notes 5-Fluorocytosine (5-FC), a fluorinated pyrimidine analog, is a synthetic antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil.{20805} 5-Fluorouracil, a widely used cytotoxic drug, is further metabolized to fluorinated ribo- and deoxyribonucleotides, resulting in the inhibition of DNA and protein synthesis, which has multiple effects including inhibition of Candida species and C. neoformans infections and cytotoxicity towards cancer cells.{20805,20804} In combination with a retroviral replicating vector carrying a cytosine deaminase prodrug-activating gene, 5-FC has been shown to selectively eliminate CT26 and Tu-2449 tumor cells in vitro (IC50s = 4.2 and 1.5 μM, respectively) and to significantly improve survival and reduce tumor size (at a dose of 500 mg/kg) in two different syngeneic mouse glioma models.{20803}
Alias Names 5-FC|Ancobon|Ancotil|NSC 103805|Ro 2-9915
Product Type Antibiotics & Culture Media
Purity ≥95%
Shipping Information -20
Size 1 g
Storage -20
Substrate / Buffer A crystalline solid
Product Page Updated 2022-01-10T15:00:37.033Z

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