Article No
154-10009650-100
Specifications
| Additional Information | A single enantiomer of a potent and selective inactivator of KIAA1363, a MAGE hydrolase an enzyme that is upregulated in aggressive cancers from various tissues (IC50 = 150 nM when tested as a racemic mixture in SK0V-3 cells); activity of the individual enantiomers of AS 115, i.e,. (+)-AS 115 and (−)-AS 115, has not been determined |
| Article No | 154-10009650-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, RU |
| Description | (+)-AS 115 |
| Supplier | Cayman Chemical |
| Format | A solution in methyl acetate |
| Notes | KIAA1363 is a 2-acetyl monoacylglyceryl ether (MAGE) hydrolase that is upregulated in aggressive cancers from various tissues.{17107} The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network.{14603} AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SKOV3.{14603} Treatment of SKOV3 cells with 10 µM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e., (+)-AS 115 and (−)-AS 115, has not been determined. |
| Product Type | Chemicals & Biochemicals |
| Purity | ≥98% |
| Shipping Information | -20 |
| Size | 100 µg |
| Storage | -20 |
| Substrate / Buffer | A solution in methyl acetate |
| Product Page Updated | 2022-01-10T15:00:37.033Z |
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