Article No
12-1009-20
Application | IHC |
Article No | 12-1009-20 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | rNX2/294 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | Recombinant Mouse Monoclonal Antibody to NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker)(Clone : rNX2/294) |
Supplier | Abeomics |
Entrez Gene ID | 4821 |
Gene Symbol | NKX2-2 |
Immunogen | Human full-length recombinant NKX2.2 protein |
Isotype | IgG1 k |
Keywords | Recombinant mouse antibodies, NKX2.2 (Neuroendocrine & Ewing s Sarcoma Marker), NKX2-2, 4821, O95096, Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman , rNX2/294, Recombinant Mouse Monoclonal Antibody to NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker)(Clone : rNX2/294), Recombinant Mouse Monoclonal Antibody to NKX2.2 (Neuroendocrine & Ewing s Sarcoma Marker) |
Notes | Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors. |
Alias Names | Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman |
Product Type | Antibodies Primary |
Protocol | Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes) |
Purification | Purified |
Shipping Information | Blue Ice |
Size | 20 µg |
Source / Host | mouse |
Species Reactivity | human |
Storage | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
Substrate / Buffer | 200 µg/ml of recombinant MAb purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
UniProt Number | O95096 |
Product Page Updated | 2024-02-06T07:35:53.072Z |