Article No
11-1020-25
14-3-3 sigma
Polyclonal Antibody to 14-3-3 sigma
Antibodies Primary
Specifications
| Application | IHC, WB |
| Article No | 11-1020-25 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone Type | polyclonal |
| Conjugation | Unconjugated |
| Description | Polyclonal Antibody to 14-3-3 sigma |
| Supplier | Abeomics |
| Entrez Gene ID | 2810 |
| Gene Symbol | SFN |
| Immunogen | Full length recombinant 14-3-3 sigma protein was used as the immunogen for this antibody. |
| Isotype | IgG |
| Notes | 14-3-3 sigma is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. There are 7 known human 14-3-3 isotypes and they play important roles in many biological activities by binding to and altering the subcellular localization and/or stability of key molecules in various signaling cascades. 14-3-3 sigma was originally characterized as a human mammary epithelium marker 1 and later rediscovered as an important molecule for cell cycle checkpoint regulation. Recently it has been reported that 14-3-3 sigma may serve as a prognosis marker predicting survival of pancreatic cancer patient treatment. 14-3-3 Sigma is the only 14-3-3 isoform induced by the tumor suppressor protein p53, in response to Gamma-irradiation and other DNA-damaging agents. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression and acts as a tumor suppressor gene that is inactivated by methylation of its 5' CpG islands in epithelial tumor cells. Two isoforms of the human proteins are produced by alternative splicing. |
| Alias Names | SFN||HME1 |
| Product Type | Antibodies Primary |
| Protocol | Western blot analysis: 1-3 µg/ml, Immunohistochemical analysis: 10 µg/ml |
| Purification | Protein A Purified |
| Research area | Cell Death |
| Shipping Information | Blue Ice |
| Size | 25 µg |
| Source / Host | rabbit |
| Species Reactivity | human |
| Storage | Store the antibody at 4⁰C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing |
| Substrate / Buffer | 25 µg in 50 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| UniProt Number | P31947 |
| Product Page Updated | 2024-04-03T14:02:41.041Z |
