14-3-3 sigma

14-3-3 sigma

Article No 11-1020-100
Product Type Antibodies Primary
Research Area Cell Death
Application IHC, WB
Format Purified
Size 100 µg

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Specifications

Country Availability SE, FI, DK, NO, IS, EE, LV, LT
Clone Type polyclonal
Data Sheet Link https://www.abeomics.com/download_pdf.php?pID=245
Description Polyclonal Antibody to 14-3-3 sigma
Supplier Abeomics
Immunogen Full length recombinant 14-3-3 sigma protein was used as the immunogen for this antibody.
Isotype IgG
Notes 14-3-3 sigma is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. There are 7 known human 14-3-3 isotypes and they play important roles in many biological activities by binding to and altering the subcellular localization and/or stability of key molecules in various signaling cascades. 14-3-3 sigma was originally characterized as a human mammary epithelium marker 1 and later rediscovered as an important molecule for cell cycle checkpoint regulation. Recently it has been reported that 14-3-3 sigma may serve as a prognosis marker predicting survival of pancreatic cancer patient treatment. 14-3-3 Sigma is the only 14-3-3 isoform induced by the tumor suppressor protein p53, in response to Gamma-irradiation and other DNA-damaging agents. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression and acts as a tumor suppressor gene that is inactivated by methylation of its 5' CpG islands in epithelial tumor cells. Two isoforms of the human proteins are produced by alternative splicing.
Alias Names SFN||HME1
Protocol Western blot analysis: 1-3 µg/ml, Immunohistochemical analysis: 10 µg/ml
Purification Protein A Chromatography
Size 100
Size Unit µg
Source / Host rabbit
Species Reactivity human
Storage Store the antibody at 4⁰C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
Substrate / Buffer 100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
UniProt Number P31947
Product Page Updated 2019-04-24T15:22:26.078Z

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Source/Host:

rabbit rabbit

Species reactivity:

human human

Product insert:

Product data sheet

Datasheet

Suggested protocols:

IHC-P

IHC-P

Western Blot

Western Blot