Article No
10-7006-25
MBD2/MBD3
Monoclonal Antibody to MBD2/MBD3 (Clone: ABM14A8)
Antibodies Primary
Specifications
| Application | FC, IHC, WB |
| Article No | 10-7006-25 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | ABM14A8 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Monoclonal Antibody to MBD2/MBD3 (Clone: ABM14A8) |
| Supplier | Abeomics |
| Entrez Gene ID | 53615 |
| Gene Symbol | MBD3 |
| Immunogen | A partial length recombinant MBD3 protein (amino acids 1-290) was used as the immunogen for this antibody. |
| Isotype | IgG1 k |
| Keywords | DNA methylation and Repair, MBD3, 53615, O95983, MBD3, ABM14A8, Monoclonal Antibody to MBD2/MBD3(Clone :ABM14A8), Anti MBD2/MBD3 Antibody, MBD2/MBD3 Antibody |
| Notes | MBD2 is a subunit of the NuRD complex that is postulated to mediate gene repression via recruitment of the complex to methylated DNA. This protein binds around 1 kb downstream of the transcription start site of a subset of 400 CpG island promoters that are characterized by the presence of active histone marks, RNA polymerase II (Pol2) and low to medium gene expression levels and H3K36me3 deposition. Methylated MBD2 is involved in silencing methylated tumor suppressor genes as well as activation of pro-metastatic genes. MBD2 also plays a key role in regulating expression of a range of genes that are associated with optimal DC (Dendritic cells) activation and function. |
| Alias Names | MBD3 |
| Product Type | Antibodies Primary |
| Protocol | Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 5 µg/ml, FACS analysis: 0.5 µg/10^6 cells |
| Purification | Protein G Purified |
| Research area | Epigenetics |
| Shipping Information | Blue Ice |
| Size | 25 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Substrate / Buffer | 25 µg in 50 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| UniProt Number | O95983 |
| Product Page Updated | 2024-04-03T14:02:41.041Z |
