Article No
10-4121-100
RIG-I
Monoclonal Antibody to RIG-I (Clone: ABM4H29)
Antibodies Primary
Specifications
| Application | FC, IHC, WB |
| Article No | 10-4121-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | ABM4H29 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Monoclonal Antibody to RIG-I (Clone: ABM4H29) |
| Supplier | Abeomics |
| Entrez Gene ID | 23586 |
| Gene Symbol | DDX58 |
| Immunogen | A partial length recombinant human RIG-I protein (amino acids 1-220) was used as the immunogen for this antibody. |
| Isotype | IgG1 k |
| Keywords | Immunology, DDX58, 23586, O95786, DDX58, ABM4H29, Monoclonal Antibody to RIG-I(Clone :ABM4H29), Anti RIG-I Antibody, RIG-I Antibody |
| Notes | RIG-I (retinoic-acid-inducible gene I), also known as DDX58 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 58) is a 925-residue cytoplasmic viral RNA receptor, critically involved in the activation of the innate immune response to RNA virus infection. It is a member of the RIG-I-like receptor (RLR) family and is an essential intracellular sensor for several 5-triphosphorylated RNA viruses. RIG-I elicits its antiviral interferon (IFN) responses by recognizing viral double-stranded RNAs (dsRNAs). Structurally it comprises a helicase domain, a C-terminal domain, and N-terminal CARDs (caspase activation recruitment domains) involved in activating MAVS (mitochondrial antiviral signaling protein). Upon binding of 5'-triphosphorylated RNA, RIG-I undergoes conformational changes and post-translational modifications that allow multimerization and interaction with the mitochondrial antiviral signaling protein (MAVS). |
| Alias Names | DDX58 |
| Product Type | Antibodies Primary |
| Protocol | Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 15 µg/ml, Flowcytometric analysis: 0.5-1µg/10^6 cells |
| Purification | Protein G Purified |
| Research area | Immunology |
| Shipping Information | Blue Ice |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Substrate / Buffer | 100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| UniProt Number | O95786 |
| Product Page Updated | 2024-04-03T14:02:41.041Z |
