Article No
10-3017-100
TLR3
Monoclonal Antibody to Mouse TLR3 (Clone: ABM24E5)
Antibodies Primary
Specifications
| Application | FC, IHC, WB |
| Article No | 10-3017-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | ABM24E5 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Monoclonal Antibody to Mouse TLR3 (Clone: ABM24E5) |
| Supplier | Abeomics |
| Entrez Gene ID | 142980 |
| Gene Symbol | Tlr3 |
| Immunogen | A partial length recombinant mTLR3 protein (amino acids 180-385) was used as the immunogen for this antibody. |
| Isotype | IgG2b k |
| Keywords | Antibody to mTLR3||Anti-mTLR3 Antibody||mTLR3 Antibody |
| Notes | Mouse Toll-like receptor 3 (mTLR3) belongs to a family of evolutionary conserved innate immune recognition molecules and recognizes double-stranded RNA, a molecular pattern associated with viral infections. It has seven exons. mTlr3 show high homology to hTLR3 in their predicted cDNA and protein sequences. The intracellular region of mTlr3 has remarkable homology with the same region of others mTlrs. mTlr3 mRNA is ubiquitously expressed in tissues, being expressed highest in spleen, kidney and lung. Its activation by the synthetic ligand polyinosine:polycytidylic acid (poly I:C) or by mRNA rapidly causes growth cone collapse and irreversibly inhibits neurite extension independent of NF-kappaB. The high levels of mTlr3 expression in Mz B cells perhaps contribute to their ability to clear antigen from the blood. |
| Alias Names | Tlr3 |
| Product Type | Antibodies Primary |
| Protocol | Western blot analysis: 2-4 µg/ml, FACS analysis: 0.5 µg/10^6 cells, Immunohistochemical analysis: 10 µg/ml |
| Purification | Protein G Purified |
| Research area | Immunology |
| Shipping Information | Blue Ice |
| Size | 100 µg |
| Source / Host | rat |
| Species Reactivity | human, mouse |
| Storage | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Substrate / Buffer | 100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| UniProt Number | Q99MB1 |
| Product Page Updated | 2024-04-03T14:02:41.041Z |
