Article No
10-1044-100
Bi-1
Monoclonal antibody to Bi-1 (Clone: ABM20E4)
Antibodies Primary
Specifications
| Application | WB |
| Article No | 10-1044-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | ABM20E4 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | Monoclonal antibody to Bi-1 (Clone: ABM20E4) |
| Supplier | Abeomics |
| Entrez Gene ID | 7009 |
| Gene Symbol | TMBIM6 |
| Immunogen | A partial length recombinant protein of human Bi-1 (amino acids 1-200) was used as an immunogen for this antibody. |
| Isotype | IgG2a k |
| Keywords | Apoptosis, TMBIM6, 7009, P55061, TMBIM6, BI1, TEGT, ABM20E4, Monoclonal Antibody to Bi-1(Clone :ABM20E4), Anti Bi-1 Antibody, Bi-1 Antibody |
| Notes | Bi-1 is an anti-apoptotic protein that inhibits Bax activation and its translocation to the mitochondria. Functionally, BI-1 affects the leakage of Ca2+ ions from the ER. In addition to its anti-apoptotic role, BI-1 also enhances cancer/tumor progression. It belongs to the Bcl-2 family, plays an important role in the mitochondrial apoptosis pathway. Bi-1 over-expression suppresses apoptosis induced by Bax, staurosporine and growth factor deprivation. BI-1 is presumably not needed for the physiological regulation of developmental programmed cell death. The anti-apoptotic mechanism of BI-1 involves the suppression of Bax activation and translocation to mitochondria, preserving the mitochondria membrane potential and mitochondrial morphology, and preventing the activation of post-mitochondrial caspases. BI-1 function is also associated with the regulation of intracellular Ca2+ omeostasis. In several human cancers, including nasopharyngeal carcinoma, its expression was found to be increased; however, up-regulated expression of this protein has been linked to increased cell proliferations. |
| Alias Names | TMBIM6||BI1||TEGT |
| Product Type | Antibodies Primary |
| Protocol | Western blot analysis: 4-6 µg/ml |
| Purification | Protein G Purified |
| Research area | Cell Death |
| Shipping Information | Blue Ice |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
| Substrate / Buffer | 100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| UniProt Number | P55061 |
| Product Page Updated | 2024-04-03T14:02:41.041Z |
