Article No
10-1019-F-100
Caspase-8
Monoclonal Antibody to Caspase-8 (Clone: ABM14C1) FITC Conjugated
Antibodies Primary
Specifications
| Application | FC |
| Article No | 10-1019-F-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | ABM14C1 |
| Clone Type | monoclonal |
| Conjugation | FITC |
| Description | Monoclonal Antibody to Caspase-8 (Clone: ABM14C1) FITC Conjugated |
| Supplier | Abeomics |
| Entrez Gene ID | 841 |
| Gene Symbol | CASP8 |
| Immunogen | A partial length recombinant protein (a.a 179-385) of Caspase-8 was used as the immunogen for this antibody. |
| Isotype | IgG1 |
| Notes | Apoptosis occurs during normal cellular development and involves dramatic changes in cellular structure. Disruption of apoptosis may contribute to cancer as well as other autoimmune diseases. Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-8 is a 55 kDa cytosolic protein that is synthesized as an inactive pro-enzyme. Activation of caspase-8 involves a two-step proteolysis: the cleavage of caspase-8 to generate a 43 and a 12 kDa fragment which is further processed to 10 kDa. The p43 is then cleaved to yield p26 and the release of the active site containing p18.The Active/Cleaved Caspase-8 polyclonal antisera recognizes the large and small subunits of active/cleaved caspase-8. Whereas the antisera has a strong preference for active/cleaved caspase-8, in some cell or tissue systems or techniques the antisera may also recognize the proform of caspase-8 as well as intermediate caspase-8 cleavage fragments. |
| Alias Names | Apoptotic cysteine protease, Apoptotic protease Mch-5, FADD-homologous ICE/ced-3-like protease, CE-like apoptotic protease 5 |
| Product Type | Antibodies Primary |
| Protocol | FACS: 0.5-1 µg/10^6 |
| Purification | Protein G Purified |
| Research area | Cell Death |
| Shipping Information | Blue Ice |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store the antibody at 4°C, stable for 6 months. Do not freeze. |
| Substrate / Buffer | 100 µg in 500 µl Tris and 0.05% sodium azide. Sodium azide is highly toxic. |
| UniProt Number | Q14790 |
| Product Page Updated | 2024-04-03T14:02:41.041Z |
