GeneTex’s Knockout-Validated CD44 Antibodies for Cancer Stem Cell Research

 

Cancer stem cells (CSCs) have been increasingly recognized as the key determinative
cells of malignancies. CD44 is a glycosylated cell surface receptor for hyaluronic acid
(HA) and many other extracellular matrix (ECM) components. It exists as a standard
isoform (CD44s) as well as a range of variants (CD44v) generated through alternative
splicing. Accumulating evidence suggests that CD44 is not only a CSC marker,
but also a critical regulator of CSC self-renewal, tumor initiation, metastasis,
and tumor chemo- and radioresistance properties.


CititionKOKDorthogonal validation

CD44 antibody(GTX102111)

 

CD44 antibody (GTX102111)

 

CD44 antibody [N1N2], N-term (GTX112893)

CD44 antibody
(GTX102111)citation KOKDOrthogonal

 

CD44 antibody
(GTX102111)citation KOKDOrthogonal

 

CD44 antibody [N1N2],
N-term (GTX112893) citationKOKD

WB analysis to detect CD44 in wild-type (WT) or CD44 knockout (KO) HeLa cells.

 

WB analysis to detect CD44s (standard isoform) and CD44v (isoform variants) in several human cell extracts.

 

IHC-P analysis to detect CD44 in a human breast carcinoma tissue section.

 

CD44 antibody [GT462] (GTX628895)

 

CD44 antibody [GT462] (GTX628895)

 

CD44 antibody [GT981] (GTX628472)

CD44 antibody [GT462] (GTX628895) citationKOKDOrthogonal

 

CD44 antibody [GT462] (GTX628895) citationKOKDOrthogonal

 

CD44 antibody [GT981](GTX628472) citationKOKD

WB analysis to detect CD44 in extracts from MDA-MB-231 cells untreated (-) or treated (+) with Tunicamycin for 16 hours to inhibit N-glycosylation.

 

Flow cytometry analysis to detect CD44 in HL-60 cells.

 

ICC/IF analysis to detect CD44 on A431 cell membranes.