Using Epitope Tags to Study Autoimmunity

Many chronic autoimmune disorders such as systemic lupus erythematosus, psoriasis, and Sjögrens syndrome are associated with an overactive Th17 response.  While Act1 (IL-17R adaptor protein) plays a role in mediating downstream IL-17 signaling, loss of Act1 results in spontaneous autoimmune diseases.  Zhang et al. utilized epitope tags to study the mechanism by which Act1 negatively regulates T and B cell activation and found that it directly binds to and inhibits STAT3 signaling thereby modulating IL-23/IL-21-dependent autoimmunity.

BioLegend offers a wide variety of epitope tag antibodies and associated reagents to help study direct protein-protein interactions and how point mutations may alter these interactions and downstream signaling events.

Adapted from Zhang et al. 2018. Nature Communications. 16:9.

Epitope Tag Antibodies

Anti c-Myc Antibodies

Anti-DYKDDDDK Tag Antibodies

Anti-HA Tag Antibodies

Anti-His Tag Antibodies

Anti-V5 Antibodies

Epitope Tag Small Motif Antibody Sampler Kit

Epitope Tag Big Motif Antibody Sampler Kit

 

Pubmed

Adapted from Zhang et al. 2018.

Nature Communications

. 16:9.

Pubmed

Adapted from Zhang et al. 2018.

Nature Communications

. 16:9.