New Optibodies are launched!
Description: Anti-Factor 8, rabbit monoclonal - Optibodies
F8 is coagulation factor VIII acting as procoagulant component. F8 participates
in the intrinsic pathway of blood coagulation. F8 is a product of the von Willebrand
factor gene, and it is expressed in endothelial cells, megakaryocytes and
thrombocytes. However, endothelial cells of large blood vessels, liver sinusoids
and lymphatics are often F8 negative. Defects in F8 gene results in hemophilia A,
a common recessive X-linked coagulation disorder. This antibody is useful for
detection of the vascular neoplasms for example with CD31 and CD34.
Description: Anti-Cytokeratin 7, mouse monoclonal - Optibodies
Cytokeratin 7 (CK7) is a protein that in humans is encoded by the KRT7 gene.
CK7 is a member of the keratin family and it is specifically expressed in the
simple epithelia lining the cavities of the internal organs and in the gland ducts.
The type II cytokeratins consist of basic or neutral proteins which are arranged in
pairs of heterotypic keratin chains co-expressed during differentiation of simple
and stratified epithelial tissues. IHC staining of cytokeratin 7 is useful for
carcinoma diagnostic especially for differential diagnosis of urothelial, lung,
breast carcinomas to colorectal or prostate carcinomas. CK7 is especially marker
of lung adenocarcinoma. Pancreas is the good tissue control for CK7.