Finally an Optibody for PAX5
Our histology lab and daughter company, BioSiteHisto, has been busy developing and validating an OptibodyTM towards the PAX 5 protein for IHC-P. This PAX 5 OptibodyTM (BSH-4007) is a rabbit monoclonal (Clone ID: BSR59) with beautiful staining in Tonsil, Colon, Hodgkin Lymphoma and DLBCL.
PAX 5 is a member of the paired box family of transcription factors. The central feature of this family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development and alterations in the expression of their genes are thought to contribute to neoplastic transformation. The PAX 5 gene encodes the B-cell lineage specific activator protein that is expressed at early but not late stages of B-cell differentiation. It is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas CD2 stained tissue sections.
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Tonsil (a), colon (b), hodgkin lymphoma (c) and DLBCL (d) sections have been stained using PAX5 OptibodyTM (Clone: BSR59) with 1:200 dilution. B-cells have strong nuclear labe in tonsil and colon sections. In hodgkin’s lymphoma, reed-stenberg cells have modeare to strong staining reaction. All neoplastic cells of DLBCL have strong nuclear staining reaction.