Understand the role of APOBEC3-based DNA demethylation in cancer or SARS-CoV-2

Introducing two new ELISA-like kits to study APOBEC3 & APOBEC3A cytidine deaminase: the Epigenase APOBEC3 Cytidine Deaminase Activity/Inhibition Assay Kit & Epigenase APOBEC3A Activity/Inhibition Assay Kit. Each kit comes with everything needed to measure APOBEC3 or APOBEC3A activity level from humans or other mammals using cell extracts or purified enzymes.

Why Study APOBEC3s?
APOBEC3 deaminases play an important role in nucleic acid editing and immunity. They are of particular interest in epigenetic studies due to their DNA demethylation functionalities and cause the dominant C-to-U mutation in the SARS-CoV-2 genome. Read more about this online: APOBEC3 Cytidine Deaminases: Viral Restriction and Cancer Therapy

Epigenase APOBEC3 Cytidine Deaminase Activity/Inhibition Assay Kit

  • Finished within 4 hours
  • Extremely low background signals
  • Uses cell/tissue extracts and purfied APOBEC3 enzymes
  • C-to-U converted standard is included for convenience
  • Flexible for manual or high throughput analysis

Epigenase APOBEC3A Activity/Inhibition Assay Kit

  • Finished within 5 hours
  • Extremely low background signals
  • Uses cell/tissue extracts and purfied APOBEC3A enzymes
  • Detection limit as low as 10 ng of purfied APOBEC3A enzymes
  • Assay standard is included for convenience
  • Flexible for manual or high throughput analysis

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