Specialized Pro-Resolving Mediators

The resolution of inflammation is an active process that is driven by unique signaling molecules. An important group of these specialized pro-resolving mediators (SPMs) is derived from polyunsaturated fatty acids (arachidonic acid (AA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA)) that are liberated during the inflammatory process.

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Featured SPMs

RCTR1

Resolvin conjugate in tissue regeneration 1 (RCTR1) is biosynthesized from docosahexaenoic acid (DHA; Item No. 154-90310) by isolated human macrophages and apoptotic polymorphonuclear (PMN) neutrophils. It has been found in human spleen and bone marrow. Learn More >>

Resolvin E4

Resolvin E4 (RvE4) is produced from eicosapentaenoic acid (EPA; Item Nos. 154-90110 | 154-90110.1 | 154-21908) by 15-lipoxygenase (15-LO) via 15(S)-HpEPE (Item No. 154-42710) and 15S-hydroxy, 5S-HpEPE intermediates in vitro and by isolated human M2 macrophages or polymorphonuclear (PMN) neutrophils under normoxic or hypoxic conditions. Learn More >>

Resolvin E2

Resolvin E2 (RvE2) is produced from eicosapentaenoic acid (EPA; Item Nos. 154-90110 | 154-90110.1 | 154-21908) via an 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils. Learn More >>

 

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