The resolution of inflammation is an active process that is driven by unique signaling molecules. An important group of these specialized pro-resolving mediators (SPMs) is derived from polyunsaturated fatty acids (arachidonic acid (AA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA)) that are liberated during the inflammatory process.
Resolvin conjugate in tissue regeneration 1 (RCTR1) is biosynthesized from docosahexaenoic acid (DHA; Item No. 154-90310) by isolated human macrophages and apoptotic polymorphonuclear (PMN) neutrophils. It has been found in human spleen and bone marrow. Learn More >>
Resolvin E4 (RvE4) is produced from eicosapentaenoic acid (EPA; Item Nos. 154-90110 | 154-90110.1 | 154-21908) by 15-lipoxygenase (15-LO) via 15(S)-HpEPE (Item No. 154-42710) and 15S-hydroxy, 5S-HpEPE intermediates in vitro and by isolated human M2 macrophages or polymorphonuclear (PMN) neutrophils under normoxic or hypoxic conditions. Learn More >>
Resolvin E2 (RvE2) is produced from eicosapentaenoic acid (EPA; Item Nos. 154-90110 | 154-90110.1 | 154-21908) via an 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils. Learn More >>
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