Simplify Your PROTAC Optimization Projects

news September 22 2022

PROTAC (Targeted Protein Degradation Using Proteolysis Targeting Chimeras) is a promising approach to downregulate proteins of therapeutic interest using targeted degradation. It has the potential to overcome the onset of drug resistance and can target previously “undruggable” proteins with high selectivity. BPS Bioscience is a leading provider of PROTAC-related products and services.

PROTAC® Optimization Kits

BPS Bioscience’s new homogenous PROTAC optimization kits are ideal for high-throughput screening or profiling of compounds targeting BET, BRD9, PARP1, or CDK kinases for cereblon-mediated degradation (BET-VHL binding assay kit is also available). Each kit includes a validated PROTAC compound as positive control.

PROTAC Optimization Assay Kits 

Intrachain TR-FRET Assay Kits for Poly-ubiquitination

The intrachain TR-FRET Assay Kits are sensitive, high-throughput screening assays designed to measure the auto-ubiquitination activity of various ubiquitin ligases in a homogeneous 384 reaction format. They use a Europium-labeled Ub donor and a Cy5-labeled Ub acceptor to complete the TR-FRET pairing. These kits support real-time kinetics analyses of poly-ubiquitination. Ideal for binding studies of CBL-B, c-CBL, Cereblon, MDM2, NEDD4, SMURF1, SMURF2, VHL, and XIAP.

Intrachain TR-FRET Assay Kits