The special AT-rich sequence-binding protein 2 (SATB2) is a DNA matrix-binding protein expressed strongly in the lower gastrointestinal epithelium. SATB2 gained plenty of attention when it was shown to be a clinical marker for colorectal carcinomas. Today, more than 95% of colorectal carcinoma can be identified with SATB2 in combination with cytokeratin 20. SATB2 antibody is the first choice to distinguish primary ovarian mucinous adenocarcinomas from colorectal metastases.
