SARS-CoV-2 and Innate Immunity

When the adaptive immune system fails to respond in full to infectious diseases, studies of the innate immune system can be highly relevant in order to understand the mechanisms behind. The complement system plays a central part.

Nordic BioSite in cooperation with HycultBiotech wants to highlight some of the available tools.

Complement and thromboinflammation in SARS-CoV-2

Literature indicates that SARS-CoV-2 can hijack the complement system, leading to conditions such as microvascular injury, thrombosis and Acute Respiratory Distress Syndrome (ARDS)
Molecules central to the complement cascades include:
C5 / C5a

Additional relevant Innate Immunity biomarkers in SARS-CoV-2

SAA-1: Serum Amyloid A is a biomarker of severe Coronavirus Disease and poor prognosis
Calprotectin (S100A8/A9): Elevated serum levels of S100A8/A9 correlate with inferior clinical outcomes in COVID-19 patients
• Alpha-Defensins (HNP1-3)