RNA isolation – bias-free extraction of your precious samples with silicon carbide technology

news February 18 2021

RNA isolation is an important step in the workflow to answer many research questions. Whether you are interested in knowing how the transcriptome of your cells changes due to a specific treatment or if you want to detect the presence of an RNA virus in your sample –you always have to isolate the RNA first. Independently of which downstream application you use to analyse your RNA, what you put in is what you get out! Quality and unbiased representation of the sample’s RNA profile are crucial to get reliable and reproducible data.

Silicon Carbide (SiC) Based RNA isolation technology

Silicon Carbide is Norgen Biotek’s proprietary technology, developed specifically for RNA isolation and proven to drastically improve RNA yield and quality compared to silica-based-technologies. Silicon carbide has a uniform binding affinity for all RNA species (including miRNAs) and, in contrast to silica, does not demonstrate a bias in favour of capturing GC-rich sequences and high molecular weight RNA fragments. The ability of capturing ultra-low RNA inputs -like for example 400 copies of viral RNA per 1 ml saliva without the need of carrier RNA- proves the high sensitivity of the SiC technology. This results in RNA isolation kits that combine highly sensitive bias-free RNA isolation with user-friendly phenol-free and straight forward protocols.

Are you ready to stop worrying about your RNA quality and start trusting that you get the complete picture of the sample’s RNA profile?

Have a look at our RNA isolation kits for different types of samples: Total RNA, Environmental RNA, RNA from saliva/blood/other body fluids, SARS-CoV-19 or any other viral RNA (psst – Norgen’s lysis buffers inactivate SARS-CoV-19 and render your samples non-infectious!). Click here for more information. Need help choosing the right kit?

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What is the next step for your samples?

Read our articles about qPCR/RT-PCR and cDNA synthesis or RNA sequencing to get some tips & tricks on how to smoothly analyse your isolated RNA.