Neutrophils play a critical role in the engulfment and destruction of invasive pathogenic microorganisms. One means by which they do this is to extrude web-like neutrophil extracellular traps (NETs) in response to infectious challenge. NETs are composed of DNA histones and multiple antimicrobial agents (e.g., myeloperoxidase (MPO), elastase, defensins, etc.). Cayman has developed several tools to study the process of NETosis.
Featured Products for NET Quantification
- Measures elastase released from stimulated neutrophils
- Does not depend upon the DNA component of NETs
- Compatible with any source of NET-producing cells.
- Detects CitH3, the one NET component that is produced almost exclusively during NET formation
- Validated in mouse bone marrow leukocytes and serum as well as human plasma and serum