GeneTex’s KO/KD-Validated Antibodies against EGFR

news July 15 2019

 

The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases (RTKs). It is able to induce cell differentiation, proliferation, motility, and survival upon activation through binding of its ligands (e.g., EGF). Ligand binding triggers trans‐autophosphorylation of critical tyrosine residues in the receptor’s cytoplasmic tail and a subsequent signaling cascade mediated through interactions with downstream factors. Ligand‐induced EGFR phosphorylation and conformational change also lead to receptor endocytosis from the plasma membrane. EGFR is mutated and/or overexpressed in some human malignancies and is the target of various cancer therapies. GeneTex proudly offers an outstanding selection of antibodies specific for EGFR and phosphorylated EGFR proteins.

EGFR Phosphorylation Sites

Citation/
Validation
Cat. No. Product Name Host & Clonality Reactivity Applications
   GTX628887 EGFR antibody [GT133] Ms mAb Hu WB, ICC/IF, IHC-P, IP
   GTX121919 EGFR antibody [N1-2], N-term Rb pAb Hu, Ms WB, ICC/IF, IHC-P, FACS, IP
  GTX133425 EGFR (phospho Thr669) antibody Rb pAb Hu WB
  GTX133600 EGFR (phospho Tyr845) antibody Rb pAb Hu WB, ICC/IF, IHC-P
  GTX133429 EGFR (phospho Tyr992) antibody Rb pAb Hu WB, ICC/IF
  GTX133601 EGFR (phospho Tyr998) antibody Rb pAb Hu WB, ICC/IF, IHC-P
  GTX133431 EGFR (phospho Tyr1045) antibody Rb pAb Hu WB, ICC/IF, IHC-P
  GTX133593 EGFR (phospho Ser1046/Ser1047) antibody Rb pAb Hu WB
   GTX132810 EGFR (phospho Tyr1068) antibody Rb pAb Hu WB, ICC/IF, IHC-P
  GTX133599 EGFR (phospho Tyr1086) antibody Rb pAb Hu WB, ICC/IF, IHC-P
  GTX133435 EGFR (phospho Tyr1148) antibody Rb pAb Hu WB, ICC/IF, IHC-P
  GTX133595 EGFR (phospho Tyr1173) antibody Rb pAb Hu WB, ICC/IF