Exosomes & Cell to Cell Communication
Evidence has been accumulating recently that Extracellular vesicles (EVs), especially exosomes, act as cellular messengers, conveying information to distant cells and tissues within the body. The exosomes contain cell-specific proteins, lipids and RNAs, which are transported to other cells, where they can alter function and/or physiology. Recent work has demonstrated the presence of distinct subsets of microRNAs within exosomes which depend upon the cell type and pathology from which they are secreted.
A study in 2021 explored the use of neuron-derived exosomes as a potential diagnostic biomarker for Alzheimer’s disease which generated exciting results! Read the publication to learn more.
Using Exosomes for Diagnostics
The emergence of miRNA as potential biomarkers of disease has made it important to assay biofluids, such as urine, plasma, serum, exosomes, and to investigate possible miRNA expression signatures that are associated with medically important phenotypes.
Product of the Week
Cell Culture Media Exosome Purification Kits
The Cell Culture Media Exosome Purification Kits provide a fast, reliable and convenient method to purify and enrich for pure intact exosomes from different cell culture media sample volumes ranging from 5 mL to 35 mL.
- Compatible with cell culture media from any species.
- No time-consuming ultracentrifugation, filtration or special syringes required.
- No precipitation reagents or overnight incubation required.
- Purified exosomes can be analyzed using NanoSight® or Electron Microscopy for assessing the approximate exosome size range and concentration.