Choosing & Using Chemical Probes

news November 09 2021

NEW Guide:
Choosing & Using Chemical Probes

Chemical probes are well-characterized small molecules that potently and selectively modulate target protein activity.

Use this guide, which includes the defining criteria for chemical probes, important “do’s and don’ts”, and a step-by-step guide for evaluating compound quality and suitability, to help you choose the best chemical probe for your experiments.



Related Items


A selective inhibitor of phosphoinositide 3-kinase α (PI3Kα)

BYL719 is equipotent against both wild type and several mutant isoforms (IC50s = 4.0-4.8 nM). It is less effective against PI3K isoforms β, γ, and δ as well as a range of related kinases. BYL719 is effective in vivo, as it dose-dependently inhibits the growth of PI3Kα-dependent xenograft tumors in mice.  Learn more.

SGC Probe Set

A library of epigenetic probes from the Structural Genomics Consortium (SGC)

The SGC, in conjunction with academic and industrial partners, has developed numerous small, drug-like molecules that inhibit or antagonize epigenetic readers, writers, and erasers. We provide these probes as part of our expanding epigenetics product portfolio. The SGC Probe Set contains a collection of these compounds each packaged as a 1 mg sample size for ease of preclinical target validation during early stages of drug discovery.  Learn More.

GSK484 (hydrochloride)

A reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme. It is selective for PAD4 over PAD1-3. GSK484 blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils.  Learn More.

You May Also Be Interested In

Small Molecule Inhibitors Selection Guide




Chemical Synthesis

Cayman Chemicals team of synthetic organic and medicinal chemists brings decades of industry experience to perform complex, multi-step organic syntheses.

Contact our experts today to learn how we can help you!