AdipoGen: Neuroscience research
AdipoGen offers a broad range of unique tools for neuroinflammation and neurodegeneration research. This includes biologically active Netrin-1 for axon outgrowth studies, the best inflammasomes research reagents to study the activation of neuroinflammation, biologically active Notch ligands, unique progranulin ELISA Kits and proteins, a broad range of adiponectin reagents, many Neurochemicals (including Gangliosides) and a unique polyglutamylation antibody.
Netrin-1 – A dependence receptor Ligand with Multiple Functions
International Edition netrin-1 is a guidance molecule that triggers either attraction or repulsion effects on migrating axons of neurons, interacting with the receptors Dcc or unc5 (A to D). It has been proposed that DCC and uNC5 are dependence receptors that, in the absence of netrin-1, promote apoptosis. This pro-apoptotic activity requires initial caspase cleavage of the receptor’s intracellular domain. Netrin-1 is therefore a pro-survival factor acting by blocking cell death induced by its unbound receptors. Netrin-1 protects neurons from death during development and favors tumor epithelial cells survival in some types of cancers. It interacts with the orphan amyloid precursor protein (APP), a protein component of the amyloid plaques that are associated with Alzheimer’s disease (AD). Netrin-1 also inhibits remyelination of neurons in Multiple Sclerosis (MS) (and other progressive demyelinating diseases) by inhibiting oligodendrocyte precursor migration.
Netrin-1 (human):Fc (human) (rec.)
✔ Full biological activity (tested by the key experts)
Neuroscience Research – 2nd Edition
For an overview on Adipogen Life Sciences enitre panel of Neuroscience Reagents please click HERE.