Science Hub

Welcome to Nordic BioSite's Life Science Blog. Here, we will provide commentary on current events and trends in biological sciences, interesting stories about important scientists, technical tips and suggestions, and much more. Read on and learn something new.
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International Day of Women and Girls in Science 2022

Today is the 7th International Day of Women and Girls in Science. On this day, which is implemented by UNESCO and UN Women – the United Nations entity dedicated to gender equality and the empowerment of women – we recognise the critical role of women and girls in science and technology.

Control Your Flow From Start to Finish!

As with most other experimental workflows, controls are critical in flow cytometry. Several types of controls may be used in a typical flow cytometry workflow, and these collectively serve one major purpose: to allow you to confidently distinguish your findings from background variation and non-specific staining and leave you with meaningful data.

Within a clinical laboratory where flow cytometry is used to stain cells for diagnostics, e.g., cancer, immunological diseases and others, or treatment monitoring purposes, controls become even more important since the experimental outcome can inform a patient’s prognosis and play a major role in decisions regarding treatment.

The Typical RNAi Workflow in 5 Steps

Andrew Fire and Craig Mello won the Nobel Prize in Physiology or Medicine in 2006, just 8 years after their breakthrough discovery of RNA interference (RNAi) as a mechanism that can degrade mRNA in a sequence-specific manner (1).

Click Chemistry for Biologists!

The term “click chemistry” was coined in 1999 at the 217th American Chemical Society annual meeting by Karl Barry Sharpless, a renowned chemist and professor in the Department of Chemistry at Scripps Research Institute’s California Campus.

In a key review in 2001, Sharpless used the phrase again to describe chemical reactions that are simple and high yielding, wide in scope, create only by-products that can be removed without chromatography, are stereospecific, and can be conducted in easily removable or benign solvents (1).

Exosomes – Because Good Things Come in Small Packages

Exosomes constitute a subtype of extracellular vesicles (EVs) that are released from the cytoplasm of most mammalian cell types. Structurally, they exist as enclosed particles surrounded by a lipid bilayer and appear as round bubbles when viewed under an electron microscope.

First discovered in 1983 by researchers studying transferrin receptors, exosomes are now increasingly recognised as key players in intercellular signalling and are demonstrated to play crucial roles in regulating tumour growth, metastasis, and angiogenesis during cancer development (1, 2).

Let it grow for Movember!

Movember, a blend of the English words for moustache and November, is a yearly month-long event set up to raise awareness about men’s health issues, such as prostate and testicular cancer, and suicide in men.

If you haven’t noticed it before, watch out for it this month – you will likely see more beards and moustaches than you’ve ever seen before, and not just on people but on cars, buses, and trains around the world too!