Article originally published on Atlas Antibodies’website and written by Dr. Laura Pozzi
Non-small cell lung cancers (NSCLCs) are epithelial lung cancers that differ from small cell lung cancers (SCLCs) by cells morphology and histology. Almost 85% of lung cancers are NSCLCs.
Examples of NSCLCs include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Still, several other types occur less frequently, and all varieties can occur in unusual histologic variants.
Although NSCLCs are less aggressive and progress more slowly than SCLCs, they are often identified later, and by the time of diagnosis, they will have already spread beyond the lungs.
Moreover, NSCLCs (in particular NSCLCs harboring KEAP1 mutations) are less sensitive and often resistant to chemotherapy, radiation, and immune checkpoint inhibitors immunotherapy compared with SCLCs.